Doxycycline is an antibacterial agent that neutralizes the activity of pathogenic microflora and is used in the treatment of infectious diseases. It is a highly active drug of the tetracycline group.
It is efficient for a wide range of pathogens. Staphylococci, streptococci, pathogens of gonorrhea, salmonellosis, E. coli, chlamydia and many others are sensitive to it.
This drug is on the WHO list of life-saving medicines.
- Brand Name: Doxycycline;
- Active Ingredient: Doxycycline;
- Manufacturer: Actavis, SunBiolab.
Drug substance Doxycycline
The active substance Doxycycline was synthesized in the 1960s. It was also used in veterinary medicine, and has since been used extensively to treat human infections.
It is a broad-spectrum antibiotic with a bacteriostatic mechanism for suppressing pathogenic microflora. Doxycycline works by disrupting the production of nutrients within cells. As a result, mature bacteria stop receiving protein and die without nutrients. New cells cannot develop and also perish.
When ingested, the bioavailability of Doxycycline reaches 90 %. It accumulates in body tissues and fluids. For this reason, the effect increases with each day of the pills use. The accumulated active substances keep blocking the activity of bacteria for some time after the end of the antibiotic therapy. So, the likelihood of the disease worsening is unlikely.
Indications for use
This antibiotic has a fairly long list of indications covering a wide range of diseases, including:
- Infectious inflammation of middle ear;
- Exacerbation of chronic bronchitis;
Doxycycline is quite effective for skin and soft tissue infections. This is a first-line antibiotic for rosacea, furunculosis and acne. It has the advantage of acting on bacteria that are actively reproduced in the sebaceous glands.
Doxycycline is effective in the treatment of urogenital infections:
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Treatment regimens and dosages
The treatment regimen depends directly on the location of the infection and the type of pathogen. But if there is no time to wait for the results of the blood tests, the patient must comply with the following standard Doxycycline instructions:
- For the treatment of pneumonia or bronchitis, take 1 tablet of Doxycycline 100 mg 1-2 times a day, for 10 days;
- For syphilis, take 3 tablets of Doxycycline 100 mg per day, for 10 days;
- For gonorrhea, chlamydia, mycoplasmic infection, take Doxycycline 100 mg 2 times a day, for 7 days;
- For the treatment of acne and rosacea, you should take a small dose of Doxycycline 50 mg per day. Treatment is long as bacteria react very slowly to therapy. The pills are taken for 6 to 12 weeks. It is necessary that the antibiotic accumulates sufficiently in the tissues of the sebaceous glands;
- For gastrointestinal and abdominal infections, take 100 mg of Doxycycline per day, for 5-7 days.
Recommendations for use
- Take the capsules with a small amount of water (approximately 150 ml).
- It is better to take the medicine between meals. The interval between taking the drug and food must be at least 1 hour. Food reduces bioavailability of active substances in blood plasma.
- Don’t take pills with milk or grapefruit juice. This can cause gastrointestinal side effects.
You should take the drug for a period indicated in the instructions. Even if you feel better, don’t stop taking the drug earlier.
For most infectious diseases, it is enough to take Doxycycline once a day. So, take the drug at any time during the day. But if you forget to take a dose, don't take a double dose the next day.
- Doxycycline can’t be used in patients under 8 years of age because it can affect bone formation. From 8 to 14 years of age, Doxycycline is prescribed only in cases where the potential benefit is higher than the potential harm to the body. The optimal age for antibiotic use is 14 years of age and older.
- In case of severe functional disorders of the kidneys and liver, Doxycycline is not prescribed.
- Doxycycline is not used with exacerbation of gastrointestinal diseases: stomach ulcer, gastritis, esophagitis.
A blood test is needed not only to determine the pathogen. It is also necessary to determine the number of leukocytes in the blood. If their count is insufficient (meaning an existing risk of leukopenia), Doxycycline is not prescribed.
Use of Doxycycline during pregnancy
Doxycycline is not used in the treatment of infectious diseases in women during pregnancy and lactation.
If it is necessary to take the antibiotic during breastfeeding, the baby should be switched to babies formula.
Possible side effects
Damage to tooth enamel and brown staining is possible only in children under 8 years of age. In adults, this symptom is unlikely.
The most common side effects in adults are as follows:
- Decreased appetite;
Adverse symptoms manifest as a result of failure to follow the dosage regimen or hypersensitivity to Doxycycline. If you’re worried about unwanted body reactions, consult with a doctor.
Doxycycline: interaction with other drugs
Absorption of Doxycycline in the intestines can be slowed down by antacids, iron preparations, and laxatives. To prevent their interaction, you should take Doxycycline 3 hours before the intake of these drugs.
Doxycycline reduces the effectiveness of penicillins and cephalosporins.
When taking Doxycycline, the effectiveness of oral contraceptives decreases. It is necessary to use additional contraceptive measures during treatment and a week after the end of the antibiotic therapy.
If used with Methoxyflurane, acute renal failure may develop, including death.
When taking Doxycycline and retinol, intracranial pressure increases.
Store in a dark place, out of the reach of children, at a temperature not exceeding 25°C.
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I absolutely recommend this drug! For the first few weeks my acne got worse, but it seemed like it was meant to be. Treatment lasted 4 months. Now my skin is clean. I liked the drug. So, I recommend it to everyone.
It works fast and efficiently
I’m shocked to know how many people complain about the side effects of Doxycycline. This was my second course of nasal sinus treatment. In both cases the antibiotic was good at fighting the infection. And I didn’t have big problems with it. I always took the pills after meals. And if I took pills on an empty stomach, I felt sick. So, I suggest you ALWAYS take these tablets after meals.
Hello! I used Doxycycline for malaria prevention before going to Africa. I took a dose of 100 mg for about 6 weeks. I had no serious side effects. Sometimes, I had stomach problems. But I don’t know whether they were related with local food or the drug.
It is very effective. I used it twice!
Last year, I used Doxycycline to treat an unpleasant infection. I was prescribed to take Doxycycline for 10 days. And as long as I used this drug, I had no problem with it
Finally, I will recover. Doxycycline helped me with sinusitis. I was allergic to the previous medication. I followed all recommendations. I had no side effects. I’m not a doctor, but I still strongly recommend this drug for treatment of sinus infections
It works well without obvious side effect
I was looking for help with the problem of acne that my first doctor couldn’t help with. Another doctor recommended Doxycycline since the previous treatment was not effective. Now I see that acne is decreasing. I really hope that this will continue on.
Very good antibiotic. I am satisfied with results.
Recently I have been prescribed Doxycycline after being bitten by an infected tick. After the third dose, the symptoms of the infection began to disappear fast. When used properly, the antibiotic acts exactly as the doctor said.
Doxycycline works fine, but I had problems with stomach and gases. The more food in your stomach, the better. A small meal two hours after taking the pill can also help.
Doxycycline totally solved my problem with STDs. At first, I had side effects such as abdominal pain, but nothing more. After 3 days I felt a significant relief, but I was not yet fully healthy. I’m sure this antibiotic can help to many people.
I’ve been using Doxycycline for about 50 days now. I should tell everyone that there is not a single red spot left on the skin. I will complete my treatment. The drug is definitely working. I had no side effects.
I would surely use Doxycycline again. After taking six doses of this drug, I felt like I was getting a slight headache. Maybe it’s a side effect, or maybe the headache had a different cause. The main thing is that my nasty urethral infection is gone.
Hi! I will tell you about my experience. I’m 21, and I’ve been prescribed Doxycycline. I was taking the drug for seven days, and I have no side effects. It is wonderful that there are such antibiotics, they really work, I recommend it to everyone.
I had an urinary tract infection, and I was prescribed this drug for the first time. First, I took 200 mg of Doxycycline per day and then reduced the dose to 100 mg. I suggest that you take the medicine with food or milk, otherwise you may vomit. Otherwise, I had no problem, and now I’m healthy.
I started taking Doxycycline recently. I hope it will relieve me of acne. Earlier I took other antibiotics without a positive result. After six weeks of treatment, I still have rash on my face, but it has significantly decreased.
Doxycycline cleaned the face from acne and helped eliminate redness under the skin. The drug did not have immediate effect, but the doctor said that it should be so. I passed a complete treatment course. If you stop taking the medicine early, pimples may come back.
I treated my infection with Doxycycline. I had no problem with this antibiotic. I felt much better in just two days. But I continued taking a 7-day treatment course.
I was prescribed Doxycycline, one 50 mg tablet twice a day. I took it for two months in a row, never missing a single dose. Four weeks after treatment, acne did not come back, I am happy!
Strongly recommend to everyone taking Doxycycline with food and plenty of water. This helped me deal with nausea and stomach cramps.