Aralen (Chloroquine Phosphate)
For many years, Aralen has been used as a drug and a preventive agent for malaria in clinical practice. The effectiveness of the drug has been documented in numerous studies since the 1940s.
At the beginning of the COVID-19 pandemic, the FDA issued an emergency order that allowed to prescribe Aralen to hospitalized patients diagnosed with COVID-19. The main purpose of the drug is to reduce symptoms and speed up recovery.
And despite the absence of longitudinal clinical studies, this drug has been used to treat COVID, in combination therapy, to speed up recovery and reduce the likelihood of death due to complications.
- Brand Name: Aralen;
- Active Ingredient: Chloroquine Phosphate;
- Manufacturer: Sanofi.
Aralen and its drug substance Chloroquine Phosphate
Chloroquine is the active substance, based on which the original drug Aralen was created. It is a synthetic form of quinine, a substance (alkaloid) found in the bark of the cinchona tree.
The exact mechanism of action of Chloroquine is not fully studied. It has been found that this active substance interferes with the protein synthesis of some protozoan parasites.
Besides, it is believed that Chloroquine exhibit antiviral activity. The drug exerts a selective effect over certain cell structures and prevents the coronavirus from releasing the genetic material necessary for reproduction.
Chloroquine Phosphate is well absorbed after oral intake. High plasma concentration and maximum therapeutic effect is achieved within one to six hours. Drug metabolism occurs in the liver. Chloroquine metabolites have therapeutic activity and are primarily excreted by kidneys.
Indications for use
Aralen is used for treatment of patients with COVID-19, including those with moderate or severe course of the disease. And although the FDA has not yet provided 100% approval of its effectiveness, according to doctors and patients, the drug helps to:
- Ease the course of the disease;
- Reduce the risk of complications.
Doctors may recommend Aralen for non-approved use within their authority to practice medicine. However, it should be noted that a single mechanism and proven methods for treatment of COVID-19 have not yet been developed. So, the use of the drug is individual and based on the clinical presentation.
Aralen can also be prescribed to patients with such diseases as:
- Extraintestinal amoebiasis.
The drug can also be used to prevent malaria.
Treatment regimens and dosages
Aralen is supplied in the form of oral tablets. Available dosages:
- 250 mg tablets;
- 500 mg tablets.
A pharmacist or your doctor will advise you on the dosage you need.
Possible treatment regimen:
- A single dose of 1000 mg;
- Then a dose of 500 mg once a day.
Currently, doctors do not know exactly what is the best dose of Aralen to prescribe for patients with the coronavirus. Good results have been achieved when using higher doses than those used to treat other diseases. With high doses, short-term (up to several weeks) treatment is usually recommended. As soon as there is an improvement in the condition of a patient, they stop taking the drug.
A single dose of 1000 mg, then a dose of 500 mg with an interval of 6 hours, and then a dose of 500 mg once a day during two days.
The recommended single dose is 500 mg. Important information: the interval between doses is 7 days. Take 1–2 doses before going to an endemic area. Take Aralen during the trip and 4–8 more doses after leaving the endemic area.
- 1000 mg approximately every 24 hours for 2 days;
- Then 500 mg every 24 hours for 14–21 days.
Recommendations for use
To get the maximum effect from using Aralen, follow these guidelines:
- Take the pills whole after a meal, with a glass of water;
- Do not take more than the recommended dose;
- Keep approximately equal time intervals between doses;
- Tell your doctor if you feel better or worse.
Avoid taking double doses or missing doses. Do not take a double dose to make up for missed doses. If you forget to take a pill, take it as soon as you remember to do it. However, if it's almost time to take the next pill, skip the missed dose and go back to your regular schedule.
When using Aralen once a week, you should not make up for the missed doses. Also, you should not make up for missed doses by reducing the intervals between doses.
It is contraindicated to use Aralen in the following cases:
- Hypersensitivity to Chloroquine or tablet ingredients;
- Hypersensitivity to 4-aminoquinoline compounds;
- Using with Amiodarone Hydrochloride (a drug used to treat certain types of tachyarrhythmias).
Before using the drug, consult with your doctor in the following cases:
- Any heart disease, especially if it is associated with a change in heart rate;
- Liver dysfunction including due to excessive alcohol consumption;
- Erythropoietic or hepatic porphyria (genetic diseases);
- Damage or dysfunction of eye retina;
- Seizures with impairment of motor and mental functions.
Patients with diabetes and without it should be warned that Aralen may cause a sharp decrease in blood sugar levels. Patients with a disposition to hypoglycemia or hypoglycemic attacks should have their plasma glucose levels checked regularly.
With the development of cardiomyopathy, the drug use should be discontinued.
Use of Aralen during pregnancy
Chloroquine gets into placenta and breast milk. This drug is not recommended for use during pregnancy or breastfeeding without first consulting a doctor.
Possible side effects
Keep it in mind that: overuse or misuse of this medicine can suppress the immune system and cause heart problems.
Side effects of Aralen that may manifest during treatment:
- Respiratory failure;
- Vision impairment;
- Corneal opacity;
- Loss of appetite;
- Decreased blood pressure;
- Extrapyramidal reactions (motor disorders);
- Tinnitus in the absence of an external sound source;
- Poor sleep and/or trouble maintaining sleep;
- Stomach cramps, pain, or discomfort;
- Increased skin sensitivity to ultraviolet or visible radiation.
Taking the tablets after meals may reduce the intensity and duration of some side effects.
Usually, Aralen is well tolerated. Most side effects are mild, especially if the drug is used in small doses for a short period of time (several weeks). They may disappear during treatment as your body adapts to the medication.
Chloroquine Phosphate: interaction with other drugs
Aralen 250 mg or 500 mg tablets should not be used with medicines for treatment of certain types of cardiac arrhythmias, such as Amiodarone Hydrochloride (Cordarone, Nexterone, Pacerone). This increases the risk of problems with heart rate.
Aralen (Chloroquine Phosphate) may affect the pharmacokinetic properties of the following drugs:
- Anticonvulsants used to treat seizures and other conditions not associated with seizure disorders;
- Digoxin (Lanacordin, Lanoxicaps, Lanoxin) – a fast-acting cardiac glycoside used to treat heart failure and some other heart problems;
- Praziquantel (Biltricide, Praziquantel) – a class of anthelmintic drugs used to treat infections caused by certain parasites;
- Ciclosporin (Ikervis, Ciqorin, Gengraf, Restasis, Cequa, Verkazia, Sandimmune, Neoral) – an immunosuppressant used to treat joint diseases, non-infectious skin diseases, after organ transplants and for other purposes.
Inform your doctor about any medications and supplements that you take, including those available without a prescription.
Store in a dry, dark place at the temperature not higher than 25C degrees.
The best offer for Aralen online on the market
Our main goal is the health of our customers. So, we offer our customers medicines only from trusted suppliers and the best service on the market. That is why, when buying Aralen in our pharmacy, you can be 100 % sure that you will receive original tablets from the manufacturer.
You can buy Aralen tablets for the treatment and relief of symptoms of COVID-19 online without leaving your home.
However, if symptoms get worse, additional medical assistance may be required. Follow the recommendations of health authorities and your doctor. In addition to Aralen, you may need antibiotics, which are also used to treat Covid-19.
Fast and safe drug delivery is the main achievement of our pharmacy. Order Aralen online and we will make your purchase easy and affordable. Spare some time, follow a few simple steps, and Aralen will be delivered to the specified address.
- Prices for Aralen and other medicines are much lower than those in local pharmacies;
- We are open every day, seven days a week, you can make a purchase at any time of the day;
- You do not need to personally go to a drug-store and waste your time.
If you do not know how to buy Aralen online, contact customer service and they will be happy to help you.
I had severe symptoms of Covid. Probably it was due to my being overweight and having high blood pressure. I took 5 doses of Aralen in 5 days, the difference was huge. I was still coughing a little, but could already breathe normally, and all body pains subsided. I had no noticeable side effects. I'm very glad I could recover.
In February, I felt sick, lost my sense of smell and had other noticeable symptoms. Express test gave a positive result for covid-19. I began to take Aralen and got better within the next 48 hours. The drug caused vomiting and stomach discomfort. But if I am ever again diagnosed with covid, I will definitely use Aralen.
I had Covid and serious breathing problems, I was very dizzy and nauseous. I felt a difference after the third dose of Aralen. Today it is my first day without Aralen, I am almost fine, only feel weak.
It's my second purchase here. I ordered Aralen 250 mg with home delivery two weeks ago. The best ratio of price and quality. Good customer service!
I've just taken the 5th dose of the 7-day treatment, and I feel great. Sometimes I have a stomach pain that disappears in about an hour. But It's much better than feeling like you can't breathe.
It seems to me that I can recommend Aralen. I avoided the terrible symptoms of Covid.
I was not lucky, and I got sick. I took Aralen for recent COVID-19 infection. Within 5 days, pain and high temperature disappeared, and I felt better. Don't forget to eat before taking these pills or otherwise you may feel nauseous.
I feel much better than before using Aralen. My chronic cough subsided and my temperature was almost normal. All Covid symptoms disappeared except for loss of taste and smell. Dizziness was the only bad thing I had.
I'm vaccinated, but I have not been revaccinated. I've just got through with COVID-19 for the first time. I'm obese and have always had breathing problems. I began to take the drug twice a day, and each dose brought some improvement. The chills disappeared, cough decreased, breathing improved. The only side effects I noticed were tinnitus and blurred vision, but they didn't bother me much. I really believe that Aralen saved me from possible hospitalization or other problems.
After my grandpa got positive test results for Covid, he was treated with this medicine. I can’t say whether the drug helped or not, but the virus gradually abated. The drug also had an interesting "side effect". Before Covid, my granddad had pain in his legs, and Aralen reduced pain and swelling.
Strongly recommend Aralen. Fast effect, high efficiency and excellent value for money. I have been using this website for many years, and it never let me down.
I am not saying that Aralen saved my life, but maybe it did. Blood oxygen saturation increased rapidly. After 5 days I felt better.
Greetings! I am so grateful for this medicine. It gives an impressive protection from Covid. The effect is VERY fast. After 3 days of using Aralen 500 mg I was more or less fine. The only other side effect I have noted was stomach upset. It's a small price to pay for recovery. In case of stomach problems, I do not recommend drinking alcohol, coffee and juices. Chamomile tea with mint and lemon helped me. Please monitor side effects and take care of your relatives.
I've got a positive test result for Covid. I took Aralen for five days, and on day 6 I could already walk normally, I recovered. I had no other side effects except for lower vision clarity, the contours of objects were blurred. After recovery, I began to see the same way as before.
I was very sick. I had a sore throat, fever, swallowing difficulties. I couldn't sleep well. Aralen helped me with Covid. I recovered from it in 2 weeks.
Great service. I bought Aralen online. It was delivered fast, and the pills were neatly packaged. The ordering process is intuitive and causes no problems. The bonus is that the medicine is a bit cheaper than other brand drugs and just as effective!
I wasn't vaccinated. Three weeks ago, I had Covid-19. I took Aralen for seven days. I had no side effects. For me, this drug was a life-saver. Recommend.
I traveled over several regions of Costa Rica. I began to use Aralen for malaria prevention 7 days before the trip. I was lucky not to get sick. No serious side effects. I had a slightly increased sensitivity to light, sunglasses helped.
I decided to share my experience. I went a path from a very severe condition to discharge from the hospital in 7 days. I'm fine now. Aralen 500 mg helped me get through this very scary time. Be sure to participate in mass vaccination, do not get sick.
I have a long list of problems related with joints. I've taken Aralen tablets for 2 weeks. They relieved me of morning joint stiffness and knee pain. Now I can sleep normally. For me, the drug was a great relief.
Aralen may have saved the life of my daughter in 2021. She was taken to hospital with pneumonia and Covid. She had body aches, fever, nausea, high temperature and the whole terrible list of things related with Covid. We began to use Aralen. The disease abated, it became easier to breathe. I'm very grateful to those who developed this medicine.
Hello, everyone! I'm 47. I had the coronavirus and severe respiratory symptoms. Sometimes, it was very difficult to breathe. Aralen makes me feel better. The doctor said that this medicine reduces the ability of the virus to reproduce in the body.
I'm very satisfied with Aralen 250 mg that I buy online. It has no side effects and reduces pain perfectly. I'll buy Aralen again.
As a whole, I had a positive experience of using Aralen. As for me, I would recommend taking the pills after meals. This way you'll have less chance of such side effects as nausea and abdominal pain.
I took Aralen for COVID-19 to recover faster. The pills relieved muscle pain, cough and throat pain. Tiredness and shortness of breath disappeared.
I am very satisfied with Aralen 250 mg tablets. I bought it online for the second time.